Delineates the role of atomic and molecular forces to define mechanobiology at cellular levels. The process of force transmission through the lipid bilayer remains at best partially-understood and the nature of the forces developed and exerted at the cell or tissue level remain a fundamental area of inquiry. Here, we pursue close examination of the mechanisms associated with force form lipids signaling in excitable cells, where lipid-protein interaction define the function of many mechanosensitive channels, from prokaryotes to humans. Furthermore, a keen understanding of these forces and the molecular machines that underlie them will allow for the development of the mechanoelectrical building blocks required for future bioengineering developments.
